Standings
| Record | Home | Road | Streak | |
| ◈ Farmington | 13-3 | 10-1 | 3-2 | Lost 1 |
| North County | 11-4 | 6-1 | 5-3 | Lost 1 |
| Arcadia Valley | 4-6 | 2-3 | 2-3 | Lost 1 |
| Potosi | 2-13 | 0-6 | 2-7 | Lost 1 |
Arcadia Valley Tigers Tennis
Head Coach: Chuck Lee • 5th year| 3/24/2021 | Arcadia Valley | @ | Poplar Bluff | L 6-3 |
| 3/31/2021 | North County | @ | Arcadia Valley | L 8-1 |
| 4/5/2021 | Arcadia Valley | @ | Crystal City | W 6-3 |
| 4/6/2021 | St. Pius | @ | Arcadia Valley | L 7-2 |
| 4/8/2021 | Cape Notre Dame | @ | Arcadia Valley | L 5-4 |
| 4/15/2021 | Crystal City | @ | Arcadia Valley | W 7-2 |
| 4/16/2021 | Arcadia Valley | @ | St. Pius | L 5-4 |
| 4/20/2021 | Arcadia Valley | @ | North County | ppd. (4/28) |
| 4/27/2021 | Potosi | @ | Arcadia Valley | W 8-1 |
| 4/28/2021 | Arcadia Valley | @ | North County, from 4/20 | ppd. |
| 4/30/2021 | Farmington Invitational | 5th place (tie) | ||
| 5/5/2021 | Arcadia Valley | @ | Dexter | W 5-4 |
| 5/7/2021 | Potosi Tournament | ppd. | ||
| 5/8/2021 | Districts | |||
| 5/11/2021 | 2-North County vs 3-Arcadia Valley | L 5-1 | ||
Farmington Knights Tennis
Head Coach: Andrew Canter • 5th year| 3/29/2021 | Farmington | @ | Cape Notre Dame | L 5-4 |
| 3/30/2021 | Festus | @ | Farmington | ppd. (4/15) |
| 4/6/2021 | Potosi | @ | Farmington | W 9-0 |
| 4/7/2021 | North County | @ | Farmington | T 3-3 (Susp., 4/21) |
| 4/8/2021 | Farmington | @ | Sikeston | W 8-1 |
| 4/10/2021 | Poplar Bluff Tournament (7 teams) | 4th place | ||
| 4/12/2021 | Windsor | @ | Farmington | W 9-0 |
| 4/14/2021 | Farmington | @ | Oakville | L 6-3 |
| 4/15/2021 | Festus | @ | Farmington, from 3/30 | W 8-1 |
| 4/19/2021 | Mehlville | @ | Farmington | W 7-2 |
| 4/20/2021 | Farmington | @ | Dexter | ppd. |
| 4/21/2021 | North County | @ | Farmington, from 4/7 | W 6-3 |
| 4/22/2021 | Camdenton | @ | Farmington | W 7-2 |
| 4/23/2021 | Waynesville Tournament (9 teams) | 4th place | ||
| 4/26/2021 | St. Pius | @ | Farmington | W 6-3 |
| 4/27/2021 | Farmington | @ | Jackson | W 5-4 |
| 4/30/2021 | Farmington Invitational | 1st place | ||
| 5/3/2021 | Farmington | @ | Poplar Bluff | W 7-2 |
| 5/5/2021 | Cape Central | @ | Farmington | W 8-1 |
| 5/11/2021 | Districts | |||
| 5/11/2021 | 1-Farmington vs 4-Sikeston | W 5-0 | ||
| 5/12/2021 | 1-Farmington vs 3-Poplar Bluff | W 5-4 | ||
| 5/17/2021 | State Quarterfinals | |||
| 5/17/2021 | Farmington vs Ladue | L 5-0 | ||
North County Raiders Tennis
Head Coach: Anna Yount • 3rd year| 3/22/2021 | Festus | @ | North County | L 5-4 |
| 3/24/2021 | North County | @ | Jackson | L 7-2 |
| 3/26/2021 | St. Pius | @ | North County | ppd. |
| 3/30/2021 | Windsor | @ | North County | W 7-2 |
| 3/31/2021 | North County | @ | Arcadia Valley | W 8-1 |
| 4/7/2021 | North County | @ | Farmington | T 3-3 (Susp., 4/21) |
| 4/8/2021 | North County | @ | Potosi | W 8-1 |
| 4/12/2021 | St. Pius | @ | North County | W 6-3 |
| 4/15/2021 | Potosi | @ | North County | W 9-0 |
| 4/20/2021 | Arcadia Valley | @ | North County | ppd. (4/28) |
| 4/21/2021 | North County | @ | Farmington, from 4/7 | L 6-3 |
| 4/22/2021 | North County | @ | Crystal City | W 7-2 |
| 4/28/2021 | Arcadia Valley | @ | North County, from 4/20 | ppd. |
| 4/29/2021 | North County | @ | Festus | W 7-2 |
| 5/3/2021 | North County | @ | St. Charles | W 6-3 |
| 5/5/2021 | Cape Notre Dame | @ | North County | W 5-4 |
| 5/6/2021 | Crystal City | @ | North County | W 9-0 |
| 5/7/2021 | Potosi Tournament | ppd. | ||
| 5/11/2021 | Districts | |||
| 5/11/2021 | 2-North County vs 3-Arcadia Valley | W 5-1 | ||
| 5/12/2021 | 1-Cape Notre Dame vs 2-North County | L 5-0 | ||
Potosi Trojans Tennis
Head Coach: Danny Mueller • 7th year| 3/22/2021 | Potosi | @ | Crystal City | W 6-3 |
| 3/25/2021 | Cape Notre Dame | @ | Potosi | ppd. (4/26) |
| 3/29/2021 | Crystal City | @ | Potosi | L 7-2 |
| 3/30/2021 | St. Pius | @ | Potosi | L 9-0 |
| 3/31/2021 | Salem | @ | Potosi | L 7-2 |
| 4/1/2021 | Potosi | @ | Festus | L 5-4 |
| 4/6/2021 | Potosi | @ | Farmington | L 9-0 |
| 4/8/2021 | North County | @ | Potosi | L 8-1 |
| 4/10/2021 | Poplar Bluff Tournament (7 teams) | 5th place (tied) | ||
| 4/12/2021 | Festus | @ | Potosi | L 7-2 |
| 4/15/2021 | Potosi | @ | North County | L 9-0 |
| 4/19/2021 | Potosi | @ | St. Pius | L 9-0 |
| 4/21/2021 | Potosi | @ | Sikeston | L 8-1 |
| 4/23/2021 | Crystal City Doubles Tournament | 3rd place | ||
| 4/26/2021 | Cape Notre Dame | @ | Potosi, from 3/25 | L 8-1 |
| 4/27/2021 | Potosi | @ | Arcadia Valley | L 8-1 |
| 5/6/2021 | Potosi | @ | Windsor | W 8-1 |
| 5/7/2021 | Potosi Tournament | ppd. | ||
| 5/10/2021 | Districts | |||
| 5/10/2021 | 4-Dexter vs 5-Potosi | L 5-1 | ||